Nutritional Supplements for High Cholesterol
So far, scientific support for the claim that any supplement or alternative medicine can safely treat high cholesterol is lacking, but some may be of use in conjunction with other therapy. Here are some supplements to consider:
1) Niacin (Vitamin B3)
Niacin, also called vitamin B3, is used to lower cholesterol. Specifically, it appears niacin lowers LDL cholesterol and triglycerides and raises “good” HDL cholesterol. Niacin also appears to significantly lower levels for another risk factor for atherosclerosis, lipoprotein A.
Niacin is available in prescription form and as a dietary supplement. The American Heart Association cautions patients to only use the prescription form of niacin. Because of side effects, niacin should not be used to lower cholesterol unless under the supervision of a qualified health practitioner.
Niacin can increase the effect of high blood pressure medication or cause nausea, indigestion, gas, diarrhea, or gout.
It can worsen peptic ulcers or trigger liver inflammation, and high blood sugar.
The most common side effect of high-dose niacin is skin flushing or hot flashes, which is caused by widening of blood vessels. Most people only notice this when they initially start taking niacin. The flushing may be lessened by taking niacin with meals.
Although high doses of niacin showed promise in combination with drugs to lower cholesterol (called statins), there are concerns that combining them could result in a potentially fatal condition called rhabdomyolysis. They shouldn’t be combined unless under the close supervision of a physician.
2) Soluble Fiber
Soluble fiber appears to reduce LDL cholesterol by reducing cholesterol absorption in the intestines. Soluble fiber binds with cholesterol so that it is excreted. Soluble fiber can be found as a dietary supplement, such as psyllium powder, or in foods such as:
- Oats, barley, rye
- Legumes (peas, beans)
- Some fruits such as apples, prunes, and berries
- Some vegetables, such as carrots, Brussels sprouts, broccoli, yams
Five to 10 grams a day of soluble fiber has been found to decrease LDL cholesterol by approximately 5 percent. The FDA allows soluble fiber products to indicate on the label that they are “heart-healthy.” Other supplements and foods high in soluble fiber include acacia fiber, glucomannan, shirataki noodles, nopal, and flaxseeds.
3) Plant Sterols and Stanols
Plant stanols and sterols (such as beta-sitosterol and sitostanol) are naturally-occurring substances found in certain plants.
Stanols are also found as dietary supplements or are added to margarine, orange juice, and dressings. Research suggests that plant stanols and sterols may help to lower cholesterol. They are similar in structure to cholesterol and may help block the absorption of cholesterol from the intestines.
The National Cholesterol Education Program recommends you take in 2 grams of plant sterols and stanols each day. The FDA allows an approved health claim on phytosterols stating, “Foods containing at least 0.65 gram per serving of vegetable oil plant sterol esters, eaten twice a day with meals for a daily total intake of at least 1.3 grams, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.”
Stanols and sterols appear to enhance the effects of other methods to lower cholesterol. In studies, people taking the statin drugs to lower cholesterol had an additional improvement in their cholesterol levels with stanols/sterols.
4) Artichoke Leaf
There is some research suggesting that artichoke leaf extract (Cynara scolymnus) may help to lower cholesterol. Artichoke leaf extract may work by limiting the synthesis of cholesterol in the body. Artichokes also contain a compound called cynarine, believed to increase bile production in the liver and speed the flow of bile from the gallbladder, both of which may increase cholesterol excretion.
A meta-analysis looked at randomized controlled trials for artichoke extract for high cholesterol. They found three studies worth analyzing and two showed some effect in lowering total cholesterol. Adverse events were mild, transient, and infrequent. The study said that larger clinical trials over longer periods are needed. The conclusion was that the evidence was not convincing, and the Cochrane Review discontinued updating its analysis of this research as of 2016.
Other supplements that have been suggested for cholesterol have less evidence of being useful. In the case of red yeast rice, there is a potential danger because it contains a naturally-occuring form of lovastatin, a prescription drug. Garlic has now been shown to be ineffective for lowering cholesterol. Other supplements and food you may see touted include policosanol, coenzyme Q10, green tea, and soy.
High cholesterol is usually treated based on total cholesterol, LDL cholesterol, and HDL cholesterol levels, plus the presence of additional risk factors for heart disease:
- Previous heart attack
- High blood pressure
- Low HDL cholesterol
- Family history of early heart disease
- Age over 45 in men and greater than 55 in women
- 10-year risk of heart attack greater than 20 percent
Using Alternative Medicine
Before you decide to use alternative medicine for high cholesterol, follow these tips:
- Talk with your doctor before starting any natural method to lower cholesterol.
- Make your doctor knows what supplements you are taking.
- Don’t discontinue any medication to lower cholesterol. Speak with your doctor if you have questions about your medication.
- Alternative medicine hasn’t been tested for safety and keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.